› 1je6

X-ray diffraction
2.5Å resolution

Structure of the MHC Class I Homolog MICB

Released:
DOI: 10.2210/pdb1je6/pdb
PDB entry 1je6 coloured by chain, front view.
PDB entry 1je6 coloured by chain, side view.
PDB entry 1je6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.
Holmes MA, Li P, Petersdorf EW, Strong RK
J Immunol 169 1395-400 (2002)
PMID: 12133964

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-173360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MHC class I polypeptide-related sequence B Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q29980 (Residues: 24-297; Coverage: 76%)
Gene names: MICB, PERB11.2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P4212
Unit cell:
a: 81.7Å b: 81.7Å c: 86.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.255 0.298
Expression system: Escherichia coli

Quick links

Citations

6 review citations

NK cell recognition.
Lanier LL. (2005)
5 more

4 mentions without citation

Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7.
Weaver et al. (2022)
3 more