› 1ji7

X-ray diffraction
1.45Å resolution

Crystal Structure of TEL SAM Polymer

Released:
DOI: 10.2210/pdb1ji7/pdb
PDB entry 1ji7 coloured by chain, front view.
PDB entry 1ji7 coloured by chain, side view.
PDB entry 1ji7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression.
Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU
EMBO J 20 4173-82 (2001)
PMID: 11483520

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154337 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor ETV6 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 89 amino acids
Theoretical weight: 10.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41212 (Residues: 47-123; Coverage: 17%)
Gene names: ETV6, TEL, TEL1
Sequence domains: Sterile alpha motif (SAM)/Pointed domain
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: C2
Unit cell:
a: 132.865Å b: 52.678Å c: 58.701Å
α: 90° β: 113.9° γ: 90°
R-values:
R R work R free
0.184 0.184 0.195
Expression system: Escherichia coli

Quick links

Citations

27 review citations

The ETS-domain transcription factor family.
Sharrocks AD. (2001)
26 more

11 mentions without citation

Genomic and biochemical insights into the specificity of ETS transcription factors.
Hollenhorst et al. (2011)
10 more