› 1jlm

X-ray diffraction
2Å resolution

I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND

Released:
DOI: 10.2210/pdb1jlm/pdb
PDB entry 1jlm coloured by chain, front view.
PDB entry 1jlm coloured by chain, side view.
PDB entry 1jlm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Two conformations of the integrin A-domain (I-domain): a pathway for activation?
Lee JO, Bankston LA, Arnaout MA, Liddington RC
Structure 3 1333-40 (1995)
PMID: 8747460

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-M Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11215 (Residues: 143-334; Coverage: 17%)
Gene names: CD11B, CR3A, ITGAM
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand MN 1 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: C2
Unit cell:
a: 135Å b: 37.1Å c: 38.5Å
α: 90° β: 92.6° γ: 90°
R-values:
R R work R free
0.219 0.219 not available
Expression system: Escherichia coli

Quick links

Citations

66 review citations

Integrins: bidirectional, allosteric signaling machines.
Hynes RO. (2002)
65 more

23 mentions without citation

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
22 more