› 1jnk

X-ray diffraction
2.3Å resolution

THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP

Released:
DOI: 10.2210/pdb1jnk/pdb
PDB entry 1jnk coloured by chain, front view.
PDB entry 1jnk coloured by chain, side view.
PDB entry 1jnk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.
Xie X, Gu Y, Fox T, Coll JT, Fleming MA, Markland W, Caron PR, Wilson KP, Su MS
Structure 6 983-91 (1998)
PMID: 9739089

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156874 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 10 Chain: A
Molecule details ›
Chain: A
Length: 423 amino acids
Theoretical weight: 48.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53779 (Residues: 1-423; Coverage: 91%)
Gene names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 51.5Å b: 71.24Å c: 107.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.274
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Signal transduction by the JNK group of MAP kinases.
Davis RJ. (2000)
19 more

33 mentions without citation

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases.
Bogoyevitch et al. (2006)
32 more