› 1jyr

X-ray diffraction
1.55Å resolution

Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide

Released:
DOI: 10.2210/pdb1jyr/pdb
PDB entry 1jyr coloured by chain, front view.
PDB entry 1jyr coloured by chain, side view.
PDB entry 1jyr coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
Nioche P, Liu WQ, Broutin I, Charbonnier F, Latreille MT, Vidal M, Roques B, Garbay C, Ducruix A
J Mol Biol 315 1167-77 (2002)
PMID: 11827484

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-158856 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 11.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 60-151; Coverage: 42%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SH2 domain
peptide: PSpYVNVQN Chain: L
Molecule details ›
Chain: L
Length: 9 amino acids
Theoretical weight: 1.07 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: P41212
Unit cell:
a: 50.8Å b: 50.8Å c: 89.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.228
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Structural systems biology: modelling protein interactions.
Aloy et al. (2006)
3 more

16 mentions without citation

MMDB: Entrez's 3D-structure database.
Chen et al. (2003)
15 more