› 1k04

X-ray diffraction
1.95Å resolution

Crystal Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase

Released:
DOI: 10.2210/pdb1k04/pdb
PDB entry 1k04 coloured by chain, front view.
PDB entry 1k04 coloured by chain, side view.
PDB entry 1k04 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of localization and signaling by the focal adhesion targeting domain.
Arold ST, Hoellerer MK, Noble ME
Structure 10 319-27 (2002)
PMID: 12005431

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170203 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05397 (Residues: 891-1052; Coverage: 15%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: C2221
Unit cell:
a: 38.426Å b: 95.555Å c: 84.821Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.243 0.27
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Paxillin: adapting to change.
Brown et al. (2004)
20 more

10 mentions without citation

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action.
Arold ST. (2011)
9 more