› 1k18

Solution NMR

Minimized Average NMR Structure of the Zinc Finger Domain of Human DNA Polymerase-alpha

Released:
DOI: 10.2210/pdb1k18/pdb
PDB entry 1k18 coloured by chain, front view.
PDB entry 1k18 coloured by chain, side view.
PDB entry 1k18 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Nuclear magnetic resonance structures of the zinc finger domain of human DNA polymerase-alpha.
Evanics F, Maurmann L, Yang WW, Bose RN
Biochim Biophys Acta 1651 163-71 (2003)
PMID: 14499601

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140799 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA polymerase alpha catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09884 (Residues: 1347-1377; Coverage: 2%)
Gene names: POLA, POLA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing followed by restrained molecular mechanics
Expression system: Not provided

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Citations

6 review citations

The elemental role of iron in DNA synthesis and repair.
Puig et al. (2017)
5 more