Function and Biology Details
Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Formamidopyrimidine-DNA glycosylase, catalytic domain
- DNA glycosylase/AP lyase, H2TH DNA-binding
- DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site
- Zinc finger, FPG/IleRS-type
- Zinc finger, DNA glycosylase/AP lyase-type
- Small ribosomal subunit protein uS13-like, H2TH
- Nei, N-terminal
- MutM-like, N-terminal
1 more domain
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Endonuclease 8 and DNA (preferred)
PDBe Complex ID:
PDB-CPX-114047 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (3 distinct):
Endonuclease 8
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 29.81 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 262 amino acids
Theoretical weight: 29.81 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
- Canonical:
P50465 (Residues: 2-263; Coverage: 100%)
Sequence domains:
- Formamidopyrimidine-DNA glycosylase N-terminal domain
- Formamidopyrimidine-DNA glycosylase H2TH domain
- Zinc finger found in FPG and IleRS
