› 1k5w

Solution NMR

THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE

Released:
DOI: 10.2210/pdb1k5w/pdb
PDB entry 1k5w coloured by chain, ensemble of 20 models, front view.
PDB entry 1k5w coloured by chain, ensemble of 20 models, side view.
PDB entry 1k5w coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.
Fernandez I, Araç D, Ubach J, Gerber SH, Shin O, Gao Y, Anderson RG, Südhof TC, Rizo J
Neuron 32 1057-69 (2001)
PMID: 11754837

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptotagmin-1 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.35 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21707 (Residues: 270-421; Coverage: 36%)
Gene name: Syt1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

39 review citations

The synaptic vesicle cycle.
Sudhof TC. (2004)
38 more

43 mentions without citation

Mechanism of neurotransmitter release coming into focus.
Rizo J. (2018)
42 more