› 1k8u

X-ray diffraction
1.15Å resolution

CRYSTAL STRUCTURE OF CALCIUM-FREE (OR APO) HUMAN S100A6; CYS3MET MUTANT (SELENOMETHIONINE DERIVATIVE)

Released:
DOI: 10.2210/pdb1k8u/pdb
PDB entry 1k8u coloured by chain, front view.
PDB entry 1k8u coloured by chain, side view.
PDB entry 1k8u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.
Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R
Structure 10 557-67 (2002)
PMID: 11937060

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A6 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06703 (Residues: 1-90; Coverage: 100%)
Gene names: CACY, S100A6
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: C2221
Unit cell:
a: 37.259Å b: 48.113Å c: 83.473Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.221
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Calcium-dependent and -independent interactions of the S100 protein family.
Santamaria-Kisiel et al. (2006)
11 more

10 mentions without citation

Zooming into the Dark Side of Human Annexin-S100 Complexes: Dynamic Alliance of Flexible Partners.
Weisz et al. (2020)
9 more