› 1k9k

X-ray diffraction
1.76Å resolution

CRYSTAL STRUCTURE OF CALCIUM BOUND HUMAN S100A6

Released:
DOI: 10.2210/pdb1k9k/pdb
PDB entry 1k9k coloured by chain, front view.
PDB entry 1k9k coloured by chain, side view.
PDB entry 1k9k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.
Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R
Structure 10 557-67 (2002)
PMID: 11937060

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-139142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 90 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06703 (Residues: 1-90; Coverage: 100%)
Gene names: CACY, S100A6
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand BME 2 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P21212
Unit cell:
a: 56.61Å b: 58.439Å c: 51.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.185 0.199
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Calcium-dependent and -independent interactions of the S100 protein family.
Santamaria-Kisiel et al. (2006)
12 more

16 mentions without citation

Principles of flexible protein-protein docking.
Andrusier et al. (2008)
15 more