› 1kbh

Solution NMR

Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR

Released:
DOI: 10.2210/pdb1kbh/pdb
PDB entry 1kbh coloured by chain, ensemble of 20 models, front view.
PDB entry 1kbh coloured by chain, ensemble of 20 models, side view.
PDB entry 1kbh coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.
Demarest SJ, Martinez-Yamout M, Chung J, Chen H, Xu W, Dyson HJ, Evans RM, Wright PE
Nature 415 549-53 (2002)
PMID: 11823864

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155302 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 3 Chain: A
Molecule details ›
Chain: A
Length: 47 amino acids
Theoretical weight: 5.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6Q9 (Residues: 1045-1091; Coverage: 3%)
Gene names: AIB1, BHLHE42, NCOA3, RAC3, TRAM1
Sequence domains: Nuclear receptor coactivator
Structure domains: Nuclear receptor coactivator, Ncoa-type, interlocking domain
Histone lysine acetyltransferase CREBBP Chain: B
Molecule details ›
Chain: B
Length: 59 amino acids
Theoretical weight: 6.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P45481 (Residues: 2059-2117; Coverage: 2%)
Gene names: Cbp, Crebbp
Sequence domains: Creb binding
Structure domains: Nuclear receptor coactivator, CREB-bp-like, interlocking domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Dyana, Sane, Amber
Expression system: Escherichia coli

Quick links

Citations

64 review citations

Intrinsically unstructured proteins and their functions.
Dyson et al. (2005)
63 more

41 mentions without citation

Malleable machines take shape in eukaryotic transcriptional regulation.
Fuxreiter et al. (2008)
40 more