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structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide

X-ray diffraction
2.1Å resolution
PDB entry 1kc2 coloured by chain, front view.
PDB entry 1kc2 coloured by chain, side view.
PDB entry 1kc2 coloured by chain, top view.
Source organism: Rous sarcoma virus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase transforming protein Src and peptide
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Multimeric state: hetero dimer
Accessible surface area: 6017.13 Å2
Buried surface area: 1036.12 Å2
Dissociation area: 476.96 Å2
Dissociation energy (ΔGdiss): 4.76 kcal/mol
Dissociation entropy (TΔSdiss): 7.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132663

Macromolecules

Tyrosine-protein kinase transforming protein Src
Chain: A
Length: 103 amino acids
Theoretical weight: 11.7 KDa
Source organism: Rous sarcoma virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00524 (Residues: 145-247; Coverage: 20%)
Gene name: V-SRC
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Tyrosine-protein kinase transforming protein Src in PDB entry 1kc2, assembly 1, front view.
Tyrosine-protein kinase transforming protein Src in PDB entry 1kc2, assembly 1, side view.
Tyrosine-protein kinase transforming protein Src in PDB entry 1kc2, assembly 1, top view.
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PQpYEEIPI peptide
Chain: B
Length: 8 amino acids
Theoretical weight: 1.07 KDa
Source organism: Rous sarcoma virus
Expression system: Not provided
PQpYEEIPI peptide in PDB entry 1kc2, assembly 1, front view.
PQpYEEIPI peptide in PDB entry 1kc2, assembly 1, side view.
PQpYEEIPI peptide in PDB entry 1kc2, assembly 1, top view.
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