› 1kcq

X-ray diffraction
1.65Å resolution

Human Gelsolin Domain 2 with a Cd2+ bound

Released:
DOI: 10.2210/pdb1kcq/pdb
PDB entry 1kcq coloured by chain, front view.
PDB entry 1kcq coloured by chain, side view.
PDB entry 1kcq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type.
Kazmirski SL, Isaacson RL, An C, Buckle A, Johnson CM, Daggett V, Fersht AR
Nat Struct Biol 9 112-6 (2002)
PMID: 11753432

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-139010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gelsolin Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06396 (Residues: 185-288; Coverage: 14%)
Gene name: GSN
Sequence domains: Gelsolin repeat
Structure domains: Severin

Ligands and Environments

1 bound ligand:
Ligand CD 4 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: C2
Unit cell:
a: 96.968Å b: 26.525Å c: 50.294Å
α: 90° β: 121.19° γ: 90°
R-values:
R R work R free
0.191 0.177 0.233
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The gelsolin family of actin regulatory proteins: modular structures, versatile functions.
McGough et al. (2003)
9 more

9 mentions without citation

Amyloidogenic sequences in native protein structures.
Tzotzos et al. (2010)
8 more