› 1kd7

X-ray diffraction
2.8Å resolution

Crystal structure of an extracellular domain fragment of human BAFF

Released:
DOI: 10.2210/pdb1kd7/pdb
PDB entry 1kd7 coloured by chain, front view.
PDB entry 1kd7 coloured by chain, side view.
PDB entry 1kd7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes.
Karpusas M, Cachero TG, Qian F, Boriack-Sjodin A, Mullen C, Strauch K, Hsu YM, Kalled SL
J Mol Biol 315 1145-54 (2002)
PMID: 11827482

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 13b, soluble form Chains: A, B, C, K, L, M
Molecule details ›
Chains: A, B, C, K, L, M
Length: 164 amino acids
Theoretical weight: 18.56 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9Y275 (Residues: 126-285; Coverage: 56%)
Gene names: BAFF, BLYS, TALL1, TNFSF13B, TNFSF20, UNQ401/PRO738, ZTNF4
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P65
Unit cell:
a: 121.72Å b: 121.72Å c: 160.74Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.217 0.25
Expression system: Komagataella pastoris

Quick links

Citations

22 review citations

BAFF AND APRIL: a tutorial on B cell survival.
Mackay et al. (2003)
21 more

6 mentions without citation

Structural conservation of druggable hot spots in protein-protein interfaces.
Kozakov et al. (2011)
5 more