› 1kdm

X-ray diffraction
2.35Å resolution

THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM)

Released:
DOI: 10.2210/pdb1kdm/pdb
PDB entry 1kdm coloured by chain, front view.
PDB entry 1kdm coloured by chain, side view.
PDB entry 1kdm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
Grishkovskaya I, Avvakumov GV, Hammond GL, Muller YA
J Mol Biol 318 621-6 (2002)
PMID: 12054810

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex hormone-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 177 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04278 (Residues: 42-158, 165-217; Coverage: 46%)
Gene name: SHBG
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand DHT 1 x DHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P4322
Unit cell:
a: 52.24Å b: 52.24Å c: 148.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 0.264
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Diverse roles for sex hormone-binding globulin in reproduction.
Hammond GL. (2011)
3 more

3 mentions without citation

Mechanical strength of 17,134 model proteins and cysteine slipknots.
Sikora et al. (2009)
2 more