› 1kf1

X-ray diffraction
2.1Å resolution

Structure and Packing of Human Telomeric DNA

Released:
DOI: 10.2210/pdb1kf1/pdb
PDB entry 1kf1 coloured by chain, front view.
PDB entry 1kf1 coloured by chain, side view.
PDB entry 1kf1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of parallel quadruplexes from human telomeric DNA.
Parkinson GN, Lee MP, Neidle S
Nature 417 876-80 (2002)
PMID: 12050675

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114079 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3 Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 6.98 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand K 3 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6
Unit cell:
a: 56.682Å b: 56.682Å c: 42.106Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.235 0.229 0.263
Expression system: Not provided

Quick links

Citations

131 review citations

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian et al. (2011)
130 more

117 mentions without citation

Quadruplex DNA: sequence, topology and structure.
Burge et al. (2006)
116 more