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Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1

X-ray diffraction
2.65Å resolution
PDB entry 1kg0 coloured by chain, front view.
PDB entry 1kg0 coloured by chain, side view.
PDB entry 1kg0 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 25035.61 Å2
Buried surface area: 8407.68 Å2
Dissociation area: 513.11 Å2
Dissociation energy (ΔGdiss): -9.03 kcal/mol
Dissociation entropy (TΔSdiss): 12.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135315

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 180 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 28-207; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1kg0, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1kg0, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1kg0, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 188 amino acids
Theoretical weight: 21.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 32-219; Coverage: 79%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1kg0, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1kg0, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1kg0, assembly 1, top view.
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Hemagglutinin HA1 chain
Chain: D
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 322-334; Coverage: 2%)
Gene name: HA
Hemagglutinin HA1 chain in PDB entry 1kg0, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 1kg0, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 1kg0, assembly 1, top view.
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Soluble gp42
Chain: C
Length: 136 amino acids
Theoretical weight: 15.63 KDa
Source organism: human gammaherpesvirus 4
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P03205 (Residues: 86-221; Coverage: 61%)
Gene name: BZLF2
InterPro:
CATH: Mannose-Binding Protein A, subunit A
SCOP: C-type lectin domain
Soluble gp42 in PDB entry 1kg0, assembly 1, front view.
Soluble gp42 in PDB entry 1kg0, assembly 1, side view.
Soluble gp42 in PDB entry 1kg0, assembly 1, top view.
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