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Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

X-ray diffraction
2.4Å resolution
PDB entry 1klg coloured by chain, front view.
PDB entry 1klg coloured by chain, side view.
PDB entry 1klg coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 27823.18 Å2
Buried surface area: 8586.92 Å2
Dissociation area: 675.66 Å2
Dissociation energy (ΔGdiss): -2.54 kcal/mol
Dissociation entropy (TΔSdiss): 13.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135328

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 177 amino acids
Theoretical weight: 20.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 29-205; Coverage: 77%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1klg, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1klg, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1klg, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1klg, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1klg, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1klg, assembly 1, top view.
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Triosephosphate isomerase
Chain: C
Length: 15 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60174 (Residues: 23-37; Coverage: 6%)
Gene names: TPI, TPI1
Triosephosphate isomerase in PDB entry 1klg, assembly 1, front view.
Triosephosphate isomerase in PDB entry 1klg, assembly 1, side view.
Triosephosphate isomerase in PDB entry 1klg, assembly 1, top view.
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Enterotoxin type C-3
Chain: D
Length: 239 amino acids
Theoretical weight: 27.72 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A0L5 (Residues: 28-266; Coverage: 100%)
Gene name: entC3
Pfam:
InterPro:
CATH:
SCOP:
Enterotoxin type C-3 in PDB entry 1klg, assembly 1, front view.
Enterotoxin type C-3 in PDB entry 1klg, assembly 1, side view.
Enterotoxin type C-3 in PDB entry 1klg, assembly 1, top view.
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