› 1kn6

Solution NMR

Solution Structure of the Mouse Prohormone Convertase 1 Pro-Domain

Released:
DOI: 10.2210/pdb1kn6/pdb
PDB entry 1kn6 coloured by chain, ensemble of 20 models, front view.
PDB entry 1kn6 coloured by chain, ensemble of 20 models, side view.
PDB entry 1kn6 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus.
Tangrea MA, Bryan PN, Sari N, Orban J
J Mol Biol 320 801-12 (2002)
PMID: 12095256

Function and Biology Details

Reaction catalysed: 
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159059 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuroendocrine convertase 1 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63239 (Residues: 28-110; Coverage: 11%)
Gene names: Att-1, Nec-1, Nec1, Pcsk1
Sequence domains: Peptidase S8 pro-domain
Structure domains: Peptidase S8, pro-domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition.
Fugère et al. (2005)
2 more

6 mentions without citation

Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin.
Shinde et al. (2011)
5 more