› 1kwm

X-ray diffraction
1.6Å resolution

Human procarboxypeptidase B: Three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI)

Released:
DOI: 10.2210/pdb1kwm/pdb
PDB entry 1kwm coloured by chain, front view.
PDB entry 1kwm coloured by chain, side view.
PDB entry 1kwm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI).
Barbosa Pereira PJ, Segura-Martín S, Oliva B, Ferrer-Orta C, Avilés FX, Coll M, Gomis-Rüth FX, Vendrell J
J Mol Biol 321 537-47 (2002)
PMID: 12162965

Function and Biology Details

Reaction catalysed: 
Preferential release of a C-terminal lysine or arginine amino acid.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase B Chains: A, B
Molecule details ›
Chains: A, B
Length: 402 amino acids
Theoretical weight: 45.96 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P15086 (Residues: 16-417; Coverage: 100%)
Gene names: CPB, CPB1, PCPB
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P21
Unit cell:
a: 42.959Å b: 83.558Å c: 127.447Å
α: 90° β: 99.12° γ: 90°
R-values:
R R work R free
0.136 0.135 0.185
Expression system: Komagataella pastoris

Quick links

Citations

6 review citations

New insights into the molecular mechanisms of the fibrinolytic system.
Rijken et al. (2009)
5 more

9 mentions without citation

Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review.
Sillen et al. (2021)
8 more