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CRYSTAL STRUCTURE OF B-12 DEPENDENT (CLASS II) RIBONUCLEOTIDE REDUCTASE

Source organism: Lactobacillus leichmannii
Biochemical function: cobalamin binding
Biological process: metabolic process
Cellular component: not assigned

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EC 1.17.4.2: Ribonucleoside-triphosphate reductase (thioredoxin)

Reaction catalysed:
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin
Systematic name:
2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase
Alternative Name(s):
  • 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase
  • Ribonucleotide reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF17975
Domain description: Ribonucleotide reductase alpha domain
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
The deposited structure of PDB entry 1l1l contains 4 copies of Pfam domain PF17975 (Ribonucleotide reductase alpha domain) in Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000788
Domain description: Ribonucleotide reductase large subunit, C-terminal
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
IPR013345
Domain description: Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
IPR040763
Domain description: Ribonucleotide reductase, alpha helical domain
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Structure domains

CATH CATH domains
3.20.70.20
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Homology: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
The deposited structure of PDB entry 1l1l contains 4 copies of CATH domain 3.20.70.20 (Anaerobic Ribonucleotide-triphosphate Reductase Large Chain) in Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase. Showing 1 copy in chain A.
3.90.1390.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: b-12 dependent (class ii) ribonucleotide reductase, chain A, domain 3
Homology: b-12 dependent (class ii) ribonucleotide reductase, chain A, domain 3
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
The deposited structure of PDB entry 1l1l contains 4 copies of CATH domain 3.90.1390.10 (b-12 dependent (class ii) ribonucleotide reductase, chain A, domain 3) in Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase. Showing 1 copy in chain A.
3.30.1620.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: b-12 dependent (class ii) ribonucleotide reductase, Chain A, Domain 2
Homology: b-12 dependent (class ii) ribonucleotide reductase, Chain A, Domain 2
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
The deposited structure of PDB entry 1l1l contains 4 copies of CATH domain 3.30.1620.10 (b-12 dependent (class ii) ribonucleotide reductase, Chain A, Domain 2) in Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase. Showing 1 copy in chain A.
SCOP SCOP annotation
75131
Class: Alpha and beta proteins (a/b)
Fold: PFL-like glycyl radical enzymes
Superfamily: PFL-like glycyl radical enzymes
Occurring in:
  1. Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
The deposited structure of PDB entry 1l1l contains 4 copies of SCOP domain 75131 (B12-dependent (class II) ribonucleotide reductase) in Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase. Showing 1 copy in chain A.

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