› 1l3h

Solution NMR

NMR structure of P41icf, a potent inhibitor of human cathepsin L

Released:
DOI: 10.2210/pdb1l3h/pdb
PDB entry 1l3h coloured by chain, ensemble of 30 models, front view.
PDB entry 1l3h coloured by chain, ensemble of 30 models, side view.
PDB entry 1l3h coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Synthesis and NMR structure of p41icf, a potent inhibitor of human cathepsin L.
Chiva C, Barthe P, Codina A, Gairí M, Molina F, Granier C, Pugnière M, Inui T, Nishio H, Nishiuchi Y, Kimura T, Sakakibara S, Albericio F, Giralt E
J Am Chem Soc 125 1508-17 (2003)
PMID: 12568610

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137528 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HLA class II histocompatibility antigen gamma chain Chain: A
Molecule details ›
Chain: A
Length: 65 amino acids
Theoretical weight: 7.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04233 (Residues: 210-274; Coverage: 22%)
Gene names: CD74, DHLAG
Sequence domains: Thyroglobulin type-1 repeat
Structure domains: Thyroglobulin type-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics and simulated annealing with restrained molecular dynamics
Expression system: Not provided

Quick links

Citations

4 review citations

Developments in peptide and amide synthesis.
Albericio F. (2004)
3 more

1 mention without citation

Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates.
Holzer et al. (2016)