› 1l3k

X-ray diffraction
1.1Å resolution

UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1

Released:
DOI: 10.2210/pdb1l3k/pdb
PDB entry 1l3k coloured by chain, front view.
PDB entry 1l3k coloured by chain, side view.
PDB entry 1l3k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1.
Vitali J, Ding J, Jiang J, Zhang Y, Krainer AR, Xu RM
Nucleic Acids Res 30 1531-8 (2002)
PMID: 11917013

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 196 amino acids
Theoretical weight: 22.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09651 (Residues: 1-196; Coverage: 53%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 37.71Å b: 43.45Å c: 55.06Å
α: 90° β: 93.7° γ: 90°
R-values:
R R work R free
0.156 0.155 0.194
Expression system: Escherichia coli

Quick links

Citations

3 review citations

hnRNP A1: the Swiss army knife of gene expression.
Jean-Philippe et al. (2013)
2 more

14 mentions without citation

Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function.
Levengood et al. (2019)
13 more