› 1l3y

Solution NMR

INTEGRIN EGF-LIKE MODULE 3 FROM THE BETA-2 SUBUNIT

Released:
DOI: 10.2210/pdb1l3y/pdb
PDB entry 1l3y coloured by chain, ensemble of 15 models, front view.
PDB entry 1l3y coloured by chain, ensemble of 15 models, side view.
PDB entry 1l3y coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
Beglova N, Blacklow SC, Takagi J, Springer TA
Nat Struct Biol 9 282-7 (2002)
PMID: 11896403

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 41 amino acids
Theoretical weight: 4.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P05107 (Residues: 535-574; Coverage: 5%)
Gene names: CD18, ITGB2, MFI7
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

58 review citations

Integrins: bidirectional, allosteric signaling machines.
Hynes RO. (2002)
57 more

2 mentions without citation

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.
Cordle et al. (2008)
1 more