› 1l6o

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156301 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Segment polarity protein dishevelled homolog DVL-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 95 amino acids
Theoretical weight: 10.59 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P51142 (Residues: 252-340; Coverage: 12%)
Gene names: dsh, dvl2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Dapper 1 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 8 amino acids
Theoretical weight: 893 Da
Source organism: Xenopus laevis
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 15 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2, null
Spacegroup: P41212
Unit cell:
a: 84.733Å b: 84.734Å c: 123.154Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.279 0.277 0.323
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

26 review citations

Dishevelled: The hub of Wnt signaling.
Gao et al. (2010)
25 more

12 mentions without citation

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.
Grandy et al. (2009)
11 more