› 1l6x

X-ray diffraction
1.65Å resolution

FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B-DOMAIN FROM PROTEIN A CALLED Z34C

Released:
DOI: 10.2210/pdb1l6x/pdb
PDB entry 1l6x coloured by chain, front view.
PDB entry 1l6x coloured by chain, side view.
PDB entry 1l6x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc.
Idusogie EE, Presta LG, Gazzano-Santoro H, Totpal K, Wong PY, Ultsch M, Meng YG, Mulkerrin MG
J Immunol 164 4178-84 (2000)
PMID: 10754313

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-134834 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1 Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01857 (Residues: 120-326; Coverage: 52%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Minimized B-domain of Protein A Z34C Chain: B
Molecule details ›
Chain: B
Length: 34 amino acids
Theoretical weight: 4.19 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2221
Unit cell:
a: 54.023Å b: 124.774Å c: 90.131Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.206 0.284
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

73 review citations

FcRn: the neonatal Fc receptor comes of age.
Roopenian et al. (2007)
72 more

43 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
42 more