› 1l9m

X-ray diffraction
2.1Å resolution

Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation

Released:
DOI: 10.2210/pdb1l9m/pdb
PDB entry 1l9m coloured by chain, front view.
PDB entry 1l9m coloured by chain, side view.
PDB entry 1l9m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.
Ahvazi B, Kim HC, Kee SH, Nemes Z, Steinert PM
EMBO J 21 2055-67 (2002)
PMID: 11980702

Function and Biology Details

Reaction catalysed: 
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)-(gamma-glutamyl)-L-lysine cross-link + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170605 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-glutamine gamma-glutamyltransferase E Chains: A, B
Molecule details ›
Chains: A, B
Length: 692 amino acids
Theoretical weight: 76.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q08188 (Residues: 2-693; Coverage: 100%)
Gene name: TGM3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand BR 2 x BR
Ligand CL 2 x CL
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P1
Unit cell:
a: 57.709Å b: 67.515Å c: 116.208Å
α: 97.24° β: 90.15° γ: 98.67°
R-values:
R R work R free
0.248 0.182 0.225
Expression system: Spodoptera frugiperda

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Citations

13 review citations

Transglutaminases: crosslinking enzymes with pleiotropic functions.
Lorand et al. (2003)
12 more

5 mentions without citation

Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.
Ahvazi et al. (2002)
4 more