› 1la6

X-ray diffraction
2Å resolution

The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state

Released:
DOI: 10.2210/pdb1la6/pdb
PDB entry 1la6 coloured by chain, front view.
PDB entry 1la6 coloured by chain, side view.
PDB entry 1la6 coloured by chain, top view.
Source organism: Trematomus newnesi
Primary publication:
The crystal structure of a tetrameric hemoglobin in a partial hemichrome state.
Riccio A, Vitagliano L, di Prisco G, Zagari A, Mazzarella L
Proc Natl Acad Sci U S A 99 9801-6 (2002)
PMID: 12093902

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155333 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 15.7 KDa
Source organism: Trematomus newnesi
UniProt:
  • Canonical: P45718 (Residues: 1-142; Coverage: 100%)
Gene name: hba1
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta-1/2 Chain: B
Molecule details ›
Chain: B
Length: 146 amino acids
Theoretical weight: 16.25 KDa
Source organism: Trematomus newnesi
UniProt:
  • Canonical: P45720 (Residues: 1-146; Coverage: 100%)
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 2 x HEM
Ligand CMO 1 x CMO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: C2
Unit cell:
a: 89.853Å b: 88.19Å c: 55.142Å
α: 90° β: 97.79° γ: 90°
R-values:
R R work R free
0.191 0.179 0.212

Quick links

Citations

5 review citations

Biopreservation of red blood cells--the struggle with hemoglobin oxidation.
Kanias et al. (2010)
4 more

4 mentions without citation

Amyotrophic lateral sclerosis: update and new developments.
Pratt et al. (2012)
3 more