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Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II

X-ray diffraction
3.2Å resolution
PDB entry 1lo5 coloured by chain, front view.
PDB entry 1lo5 coloured by chain, side view.
PDB entry 1lo5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 29158.13 Å2
Buried surface area: 8357.39 Å2
Dissociation area: 567.03 Å2
Dissociation energy (ΔGdiss): -5.18 kcal/mol
Dissociation entropy (TΔSdiss): 13.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135325

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 182 amino acids
Theoretical weight: 21.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1lo5, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1lo5, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1lo5, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1lo5, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1lo5, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1lo5, assembly 1, top view.
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Hemagglutinin peptide
Chain: C
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Hemagglutinin peptide in PDB entry 1lo5, assembly 1, front view.
Hemagglutinin peptide in PDB entry 1lo5, assembly 1, side view.
Hemagglutinin peptide in PDB entry 1lo5, assembly 1, top view.
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Enterotoxin type A
Chain: D
Length: 233 amino acids
Theoretical weight: 27.09 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A0L2 (Residues: 25-257; Coverage: 100%)
Gene name: entA
Pfam:
InterPro:
CATH:
SCOP:
Enterotoxin type A in PDB entry 1lo5, assembly 1, front view.
Enterotoxin type A in PDB entry 1lo5, assembly 1, side view.
Enterotoxin type A in PDB entry 1lo5, assembly 1, top view.
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