› 1luf

X-ray diffraction
2.05Å resolution

Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation

Released:
DOI: 10.2210/pdb1luf/pdb
PDB entry 1luf coloured by chain, front view.
PDB entry 1luf coloured by chain, side view.
PDB entry 1luf coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Till JH, Becerra M, Watty A, Lu Y, Ma Y, Neubert TA, Burden SJ, Hubbard SR
Structure 10 1187-96 (2002)
PMID: 12220490

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178970 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Muscle, skeletal receptor tyrosine protein kinase Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.75 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q62838 (Residues: 529-868; Coverage: 40%)
Gene name: Musk
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: I4
Unit cell:
a: 146.939Å b: 146.939Å c: 39.017Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.246
Expression system: Spodoptera frugiperda

Quick links

Citations

27 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
26 more

11 mentions without citation

Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?
Collins et al. (2012)
10 more