› 1lxa

X-ray diffraction
2.6Å resolution

UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE

Released:
DOI: 10.2210/pdb1lxa/pdb
PDB entry 1lxa coloured by chain, front view.
PDB entry 1lxa coloured by chain, side view.
PDB entry 1lxa coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase.
Raetz CR, Roderick SL
Science 270 997-1000 (1995)
PMID: 7481807

Function and Biology Details

Reaction catalysed: 
A (3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = an [acyl-carrier-protein] + a UDP-3-O-(3-hydroxyacylyl)-N-acetyl-alpha-D-glucosamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 28.12 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A722 (Residues: 1-262; Coverage: 100%)
Gene names: JW0176, b0181, lpxA
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P213
Unit cell:
a: 99Å b: 99Å c: 99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 not available
Expression system: Escherichia coli

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Citations

42 review citations

Lipopolysaccharide endotoxins.
Raetz et al. (2002)
41 more

31 mentions without citation

Lipid A modification systems in gram-negative bacteria.
Raetz et al. (2007)
30 more