› 1lxe

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE CATHELICIDIN MOTIF OF PROTEGRINS

Released:
DOI: 10.2210/pdb1lxe/pdb
PDB entry 1lxe coloured by chain, front view.
PDB entry 1lxe coloured by chain, side view.
PDB entry 1lxe coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein.
Sanchez JF, Hoh F, Strub MP, Aumelas A, Dumas C
Structure 10 1363-70 (2002)
PMID: 12377122

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protegrin-3 Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.32 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P32196 (Residues: 30-130; Coverage: 84%)
Gene name: NPG3
Sequence domains: Cathelicidin
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6522
Unit cell:
a: 52.172Å b: 52.172Å c: 135.483Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.215 0.279
Expression system: Escherichia coli BL21(DE3)

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Citations

7 review citations

Cathelicidins, multifunctional peptides of the innate immunity.
Zanetti M. (2004)
6 more

1 mention without citation

4SCOPmap: automated assignment of protein structures to evolutionary superfamilies.
Cheek et al. (2004)