› 1m0z

X-ray diffraction
1.85Å resolution

Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha

Released:
DOI: 10.2210/pdb1m0z/pdb
PDB entry 1m0z coloured by chain, front view.
PDB entry 1m0z coloured by chain, side view.
PDB entry 1m0z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.
Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P
Science 297 1176-9 (2002)
PMID: 12183630

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycocalicin Chains: A, B
Molecule details ›
Chains: A, B
Length: 290 amino acids
Theoretical weight: 32.37 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: P07359 (Residues: 17-306; Coverage: 46%)
Gene name: GP1BA
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 121.5Å b: 54.5Å c: 101.8Å
α: 90° β: 103.7° γ: 90°
R-values:
R R work R free
0.189 0.186 0.216
Expression system: Mesocricetus auratus

Quick links

Citations

83 review citations

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor.
Sadler et al. (2006)
82 more

11 mentions without citation

The molecular structure of the Toll-like receptor 3 ligand-binding domain.
Bell et al. (2005)
10 more