› 1m12

Solution NMR

NMR solution structure of human Saposin C

Released:
DOI: 10.2210/pdb1m12/pdb
PDB entry 1m12 coloured by chain, ensemble of 20 models, front view.
PDB entry 1m12 coloured by chain, ensemble of 20 models, side view.
PDB entry 1m12 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles.
de Alba E, Weiler S, Tjandra N
Biochemistry 42 14729-40 (2003)
PMID: 14674747

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Saposin-C Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07602 (Residues: 311-390; Coverage: 16%)
Gene names: GLBA, PSAP, SAP1
Sequence domains:
Structure domains: Saposin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry and simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.
Kolter et al. (2005)
14 more

7 mentions without citation

A short guided tour through functional and structural features of saposin-like proteins.
Bruhn H. (2005)
6 more