› 1m47

X-ray diffraction
1.99Å resolution

Crystal Structure of Human Interleukin-2

Released:
DOI: 10.2210/pdb1m47/pdb
PDB entry 1m47 coloured by chain, front view.
PDB entry 1m47 coloured by chain, side view.
PDB entry 1m47 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding of small molecules to an adaptive protein-protein interface.
Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC
Proc Natl Acad Sci U S A 100 1603-8 (2003)
PMID: 12582206

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-2 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P60568 (Residues: 21-153; Coverage: 100%)
Gene name: IL2
Sequence domains: Interleukin 2
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P21212
Unit cell:
a: 49.465Å b: 84.777Å c: 31.712Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.245
Expression system: Escherichia coli BL21

Quick links

Citations

55 review citations

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells et al. (2007)
54 more

30 mentions without citation

Computer-aided design of amino acid-based therapeutics: a review.
Farhadi et al. (2018)
29 more