› 1m4l

X-ray diffraction
1.25Å resolution

STRUCTURE OF NATIVE CARBOXYPEPTIDASE A AT 1.25 RESOLUTION

Released:
DOI: 10.2210/pdb1m4l/pdb
PDB entry 1m4l coloured by chain, front view.
PDB entry 1m4l coloured by chain, side view.
PDB entry 1m4l coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Refined structure of bovine carboxypeptidase A at 1.25 A resolution.
Kilshtain-Vardi A, Glick M, Greenblatt HM, Goldblum A, Shoham G
Acta Crystallogr D Biol Crystallogr 59 323-33 (2003)
PMID: 12554943

Function and Biology Details

Reaction catalysed: 
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133045 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase A1 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 34.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00730 (Residues: 111-417; Coverage: 76%)
Gene names: CPA, CPA1
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P21
Unit cell:
a: 51.687Å b: 60.267Å c: 47.453Å
α: 90° β: 97.47° γ: 90°
R-values:
R R work R free
0.104 0.104 0.145

Quick links

Citations

2 review citations

Molecular and genetic features of zinc transporters in physiology and pathogenesis.
Fukada et al. (2011)
1 more

5 mentions without citation

Structure of aspartoacylase, the brain enzyme impaired in Canavan disease.
Bitto et al. (2007)
4 more