› 1m5a

X-ray diffraction
1.2Å resolution

Crystal Structure of 2-Co(2+)-Insulin at 1.2A Resolution

Released:
DOI: 10.2210/pdb1m5a/pdb
PDB entry 1m5a coloured by chain, front view.
PDB entry 1m5a coloured by chain, side view.
PDB entry 1m5a coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
The high-resolution structure of hexameric T6 cobalt insulin: A possible pathway for the T to R transition.
Nicholson JM, Perkins LC, Korber FC
Recent Research Developments in Molecular Biology 3 1-17 (2006)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134248 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 88-108; Coverage: 25%)
Gene name: INS
Insulin B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 25-54; Coverage: 36%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

1 bound ligand:
Ligand CO 2 x CO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2, SRS BEAMLINE PX9.6
Spacegroup: R3
Unit cell:
a: 80.75Å b: 80.75Å c: 33.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.181 0.241

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