› 1m6b

X-ray diffraction
2.6Å resolution

Structure of the HER3 (ERBB3) Extracellular Domain

Released:
DOI: 10.2210/pdb1m6b/pdb
PDB entry 1m6b coloured by chain, front view.
PDB entry 1m6b coloured by chain, side view.
PDB entry 1m6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the extracellular region of HER3 reveals an interdomain tether.
Cho HS, Leahy DJ
Science 297 1330-3 (2002)
PMID: 12154198

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149447 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Receptor tyrosine-protein kinase erbB-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 621 amino acids
Theoretical weight: 68.38 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P21860 (Residues: 20-640; Coverage: 47%)
Gene names: ERBB3, HER3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 13 x NAG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 236.26Å b: 49.62Å c: 190.86Å
α: 90° β: 125.56° γ: 90°
R-values:
R R work R free
0.238 0.235 0.294
Expression system: Cricetulus griseus

Quick links

Citations

72 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
71 more

27 mentions without citation

Structure-based view of epidermal growth factor receptor regulation.
Ferguson KM. (2008)
26 more