› 1maz

X-ray diffraction
2.2Å resolution

X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH

Released:
DOI: 10.2210/pdb1maz/pdb
PDB entry 1maz coloured by chain, front view.
PDB entry 1maz coloured by chain, side view.
PDB entry 1maz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW
Nature 381 335-41 (1996)
PMID: 8692274

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 24.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07817 (Residues: 1-210; Coverage: 90%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 63.5Å b: 63.5Å c: 110.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.259
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

300 review citations

The biochemistry of apoptosis.
Hengartner et al. (2000)
299 more

28 mentions without citation

A functional-phylogenetic classification system for transmembrane solute transporters.
Saier MH. (2000)
27 more