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Crystal structure of Drosophila melanogaster alcohol dehydrogenase complexed with NADH and acetate at 1.6 A

Source organism: Drosophila melanogaster
Biochemical function: protein homodimerization activity
Biological process: behavioral response to ethanol
Cellular component: cytosol

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EC 1.1.1.1: Alcohol dehydrogenase

Reaction catalysed:
A primary alcohol + NAD(+) = an aldehyde + NADH
Systematic name:
Alcohol:NAD(+) oxidoreductase
Alternative Name(s):
  • ADH
  • Alcohol dehydrogenase (NAD)
  • Aldehyde reductase
  • Aliphatic alcohol dehydrogenase
  • Ethanol dehydrogenase
  • NAD-dependent alcohol dehydrogenase
  • NAD-specific aromatic alcohol dehydrogenase
  • NADH-alcohol dehydrogenase
  • NADH-aldehyde dehydrogenase
  • Primary alcohol dehydrogenase
  • Yeast alcohol dehydrogenase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00106
Domain description: short chain dehydrogenase
Occurring in:
  1. Alcohol dehydrogenase
The deposited structure of PDB entry 1mg5 contains 2 copies of Pfam domain PF00106 (short chain dehydrogenase) in Alcohol dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002425
Domain description: Alcohol dehydrogenase, Drosophila-type
Occurring in:
  1. Alcohol dehydrogenase
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. Alcohol dehydrogenase
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. Alcohol dehydrogenase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Alcohol dehydrogenase

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Alcohol dehydrogenase
The deposited structure of PDB entry 1mg5 contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Alcohol dehydrogenase. Showing 1 copy in chain A.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Alcohol dehydrogenase
The deposited structure of PDB entry 1mg5 contains 2 copies of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in Alcohol dehydrogenase. Showing 1 copy in chain A.

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