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Solution NMR

THE SOLUTION STRUCTURE OF MELANOMA GROWTH STIMULATING ACTIVITY

Released:
DOI: 10.2210/pdb1mgs/pdb
PDB entry 1mgs coloured by chain, ensemble of 25 models, front view.
PDB entry 1mgs coloured by chain, ensemble of 25 models, side view.
PDB entry 1mgs coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of melanoma growth stimulating activity.
Fairbrother WJ, Reilly D, Colby TJ, Hesselgesser J, Horuk R
J Mol Biol 242 252-70 (1994)
PMID: 8089846

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth-regulated alpha protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 73 amino acids
Theoretical weight: 7.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09341 (Residues: 35-107; Coverage: 100%)
Gene names: CXCL1, GRO, GRO1, GROA, MGSA, SCYB1
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

9 review citations

Human chemokines: an update.
Baggiolini et al. (1997)
8 more

11 mentions without citation

CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space.
Korbecki et al. (2022)
10 more