› 1mjs

X-ray diffraction
1.91Å resolution

MH2 domain of transcriptional factor SMAD3

Released:
DOI: 10.2210/pdb1mjs/pdb
PDB entry 1mjs coloured by chain, front view.
PDB entry 1mjs coloured by chain, side view.
PDB entry 1mjs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control.
Qin BY, Lam SS, Correia JJ, Lin K
Genes Dev 16 1950-63 (2002)
PMID: 12154125

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mothers against decapentaplegic homolog 3 Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 22.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P84022 (Residues: 229-425; Coverage: 46%)
Gene names: MADH3, SMAD3
Sequence domains: MH2 domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P32
Unit cell:
a: 54.325Å b: 54.325Å c: 59.428Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.196 0.199
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Specificity and versatility in tgf-beta signaling through Smads.
Feng et al. (2005)
24 more

8 mentions without citation

Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling.
Das et al. (2019)
7 more