› 1mm7

X-ray diffraction
1.65Å resolution

Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc Crystal Form at 1.65 Angstroms Resolution

Released:
DOI: 10.2210/pdb1mm7/pdb
PDB entry 1mm7 coloured by chain, front view.
PDB entry 1mm7 coloured by chain, side view.
PDB entry 1mm7 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate.
Jin R, Horning M, Mayer ML, Gouaux E
Biochemistry 41 15635-43 (2002)
PMID: 12501192

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand ZN 5 x ZN
Ligand QUS 3 x QUS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 113.912Å b: 163.453Å c: 47.336Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
15 more

3 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
2 more