1mq8

X-ray diffraction
3.3Å resolution

Crystal structure of alphaL I domain in complex with ICAM-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138633 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Intercellular adhesion molecule 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 291 amino acids
Theoretical weight: 31.62 KDa
Source organism: Homo sapiens
Expression system: Schneider S2 insect cells
UniProt:
  • Canonical: P05362 (Residues: 28-318; Coverage: 58%)
Gene name: ICAM1
Sequence domains:
Structure domains: Immunoglobulins
Integrin alpha-L Chains: B, D
Molecule details ›
Chains: B, D
Length: 177 amino acids
Theoretical weight: 20.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20701 (Residues: 155-331; Coverage: 16%)
Gene names: CD11A, ITGAL
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 46.56Å b: 62.868Å c: 81.517Å
α: 95.39° β: 106.67° γ: 90°
R-values:
R R work R free
0.28 0.264 0.313
Expression systems:
  • Schneider S2 insect cells
  • Escherichia coli BL21(DE3)