Function and Biology Details
Reaction catalysed:
GDP-D-mannose + 2 NAD(+) + H(2)O = GDP-D-mannuronate + 2 NADH
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- UDP-glucose/GDP-mannose dehydrogenase, C-terminal
- UDP-glucose/GDP-mannose dehydrogenase
- UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily
- UDP-glucose/GDP-mannose dehydrogenase, dimerisation
- 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
- NAD(P)-binding domain superfamily
- GDP-mannose 6-dehydrogenase
- UDP-glucose/GDP-mannose dehydrogenase, N-terminal
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
GDP-mannose 6-dehydrogenase (preferred)
PDBe Complex ID:
PDB-CPX-145915 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
GDP-mannose 6-dehydrogenase
Molecule details ›
Chains: A, B, C, D
Length: 436 amino acids
Theoretical weight: 48.08 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 436 amino acids
Theoretical weight: 48.08 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P11759 (Residues: 1-436; Coverage: 100%)
Sequence domains:
- UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
- UDP-glucose/GDP-mannose dehydrogenase family, central domain
- UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
