› 1n0j

X-ray diffraction
2.2Å resolution

The Structure of Human Mitochondrial MN3+ Superoxide Dismutase Reveals a Novel Tetrameric Interface of Two 4-Helix Bundles

Released:
DOI: 10.2210/pdb1n0j/pdb
PDB entry 1n0j coloured by chain, front view.
PDB entry 1n0j coloured by chain, side view.
PDB entry 1n0j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles.
Borgstahl GE, Parge HE, Hickey MJ, Beyer WF, Hallewell RA, Tainer JA
Cell 71 107-18 (1992)
PMID: 1394426

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137485 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Mn], mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04179 (Residues: 25-222; Coverage: 89%)
Gene name: SOD2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MN 2 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 76.13Å b: 79.9Å c: 68.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.171 not available
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Superoxide dismutases: role in redox signaling, vascular function, and diseases.
Fukai et al. (2011)
45 more

9 mentions without citation

MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx.
Candas et al. (2014)
8 more