› 1n26

X-ray diffraction
2.4Å resolution

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain

Released:
DOI: 10.2210/pdb1n26/pdb
PDB entry 1n26 coloured by chain, front view.
PDB entry 1n26 coloured by chain, side view.
PDB entry 1n26 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain.
Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ
Proc Natl Acad Sci U S A 99 15959-64 (2002)
PMID: 12461182

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Soluble interleukin-6 receptor subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.41 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08887 (Residues: 20-344; Coverage: 72%)
Gene name: IL6R
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, NDG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 2 x SO4
Ligand CYS 1 x CYS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE, RIGAKU RUH3R, APS BEAMLINE 14-BM-C, null
Spacegroup: P43212
Unit cell:
a: 51.13Å b: 51.13Å c: 303.388Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.29
Expression system: Cricetulus griseus

Quick links

Citations

15 review citations

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Heinrich et al. (2003)
14 more

37 mentions without citation

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Metcalfe et al. (2020)
36 more