› 1n5g

Solution NMR

NMR Structures of the Zinc Finger Domain of Human DNA Polymerase-alpha

Released:
DOI: 10.2210/pdb1n5g/pdb
PDB entry 1n5g coloured by chain, ensemble of 29 models, front view.
PDB entry 1n5g coloured by chain, ensemble of 29 models, side view.
PDB entry 1n5g coloured by chain, ensemble of 29 models, top view.
Source organism: Homo sapiens
Primary publication:
Nuclear magnetic resonance structures of the zinc finger domain of human DNA polymerase-alpha.
Evanics F, Maurmann L, Yang WW, Bose RN
Biochim Biophys Acta 1651 163-71 (2003)
PMID: 14499601

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140799 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA polymerase alpha catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 4.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09884 (Residues: 1345-1382; Coverage: 3%)
Gene names: POLA, POLA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing and constrained molecular dynamics simulations
Expression system: Not provided

Quick links

Citations

6 review citations

The elemental role of iron in DNA synthesis and repair.
Puig et al. (2017)
5 more

1 mention without citation

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors.
Tahirov et al. (2009)