› 1ncg

X-ray diffraction
2.1Å resolution

STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS

Released:
DOI: 10.2210/pdb1ncg/pdb
PDB entry 1ncg coloured by chain, front view.
PDB entry 1ncg coloured by chain, side view.
PDB entry 1ncg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of cell-cell adhesion by cadherins.
Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, Grübel G, Legrand JF, Als-Nielsen J, Colman DR, Hendrickson WA
Nature 374 327-37 (1995)
PMID: 7885471

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-2 Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.24 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P15116 (Residues: 160-267; Coverage: 12%)
Gene name: Cdh2
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand YB 1 x YB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P6322
Unit cell:
a: 77.6Å b: 77.6Å c: 74.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 0.201
Expression system: Escherichia coli

Quick links

Citations

201 review citations

Cell adhesion: the molecular basis of tissue architecture and morphogenesis.
Gumbiner BM. (1996)
200 more

7 mentions without citation

Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography.
Häussinger et al. (2004)
6 more